Author, Year	Study design, LOE*	Participants	Regimen		Route		Primary outcome	AE (s)	FU (weeks)
Hyperandrogenism – acne, hirsutism
Pezza et al,[@350873] 2015	RCT, 1b	50 PCOS women with acne		Inositol, 2 g, BID		Oral	Decreased number of papulopustular lesions	None	6
Fabbrocini et al,[@350882] 2017	Uncontrolled clinical trial, 2b	40 women with adult female acne		4% MI and 1% trehalose-loaded liposomes, overnight every other day		Peel-off facial mask	Significantly reduced mean count of comedones (-3.9), papule (-6.1), pustule (-2.0), and nodular (-0.5) lesion (P<0.001) Global acne grading score reduced from 16.8±5.3 to 9.8±4.6 (P<0.001) Sabotage score decreased from 3.4±0.6 to 1.8±0.2 (P<0.001)	None	2
Fruzzetti et al,[@350872] 2017	RCT, 1b	25 PCOS women		MI, 4 g, QD plus folic acid, 400 mcg, QD		Oral	Patient-self assessment, 20% felt a slight improvement in hirsutism, the remaining reported no change 38% felt a slight improvement in acne, 12% reported worsening, the remaining reported no change	None	6
Minozzi et al,[@350881] 2008	Uncontrolled clinical trial, 2b	46 women with mild to moderate hirsutism		MI, 2 g, BID		Oral	Hirsutism score decreased by -2.3±0.9 (P<0.001)	None	6
Advani et al,[@350878] 2020	Controlled clinical trial, 2b	Obese (35) or lean (16) PCOS women*		Trazer F Forte, BID: Inositol (MI:DCI) 600 mg, NAC 300 mg, Biotin 5 mg, 10% Lycopene 5 mg, Chromium picolinate 200 mcg, Folic Acid 120 mcg, Vitamin D 400 IU		Oral tablet	In the obese and lean group, Acne score scores -10.05 (P<0.001) and -4.38 (P<0.01), respectively Hirsutism score scores -0.45 (P<0.01) and -0.25 (P<0.05), respectively	None	3
Ramanan et al,[@350880] 2020	Uncontrolled clinical trial, 2b	32 females with mild-to-moderate acne and hirsutism		Tracnil, BID: MI, 2 g; folic acid 1 mg, vit D3 1000 IU		Oral powder sachets	GA scores reduced from 4.34±0.33 to 1.3±0.14 by Weeks 24 Modified Ferriman-Gallwey hirsutism score reduced to 8.6, 7.4, and 5.8 by Weeks 4, 12, and 24, respectively	Mild GID in some patients	6
Inflammatory dermatosis – seborrheic dermatitis, hidradenitis suppurativa, psoriasis
Allan et al,[@350876] 2004	Crossover RCT, 1b	Patients on lithium who developed chronic plaque psoriasis (15) or patients not on lithium with psoriasis (8)	Inositol, 6 g, QD		Oral		Patients on lithium: PASI scores -1.7 in the inositol group compared to +1.9 in the placebo group (P>0.05) Patients not on lithium: PASI scores +0.7 in the inositol group compared to -0.75 in the placebo group (P=0.015)	None	2.5
Dall’ Oglio et al,[@350879] 2017	Uncontrolled clinical trial, 2b	25 patients with mild-to-moderate SD	GPI, piroctone olamine, lactoferrin, and Aloe vera, BID		Topical gel		Excellent response (IGA = 4) in 47.9% of patients and no case of worsening (IGA = 0) Significant reduction in desquamation, erythema, and pruritus (P<0.001)	None	1.5
Donnarumma et al,[@350875] 2020	RCT, 1b	10 patients with HS	Antibiotics with MI 2 g, liposomal magnesium and folic acid, BID		Oral		Reduction of Sartorius scores from 38.3±7.5 to 27.3±13.53 (P<0.04)	None	6
Owczarczyk-Saczonek et al,[@350874] 2021	RCT, 1b	46 patients with mild plaque psoriasis (PASI<10, BSA<10%)	1% (B) or 0.25% (C) DCI, 1 fingertip unit, BID, or placebo applied to three different psoriatic plaques		Topical cream		Visual analogue scale reduced by 22% and 33% in the B and C group; and 23% in the placebo group (P<0.05) Plaque severity index reduced by 30% and 45% in the B and C group; and 28% in the placebo group (P<0.05)	Not reported	1.5
Psychodermatoses – skin picking, trichotillomania
Seedat et al,[@350883] 2001	Case series, 4	3 patients with trichotillomania and compulsive skin picking	Inositol, 6 g, TID (primary treatment in two and adjunct to SRI in one)		Oral powder dissolved in water or juice		Two patients reported a CGI-I score of 2 (much improved), and 1 (adjunct to SRI) reported CGI-I of 1 (very much improved)	Mild GID (2) and headache (1)	2-3
Leppink et al,[@350877] 2017	RCT, 1b	19 patients with trichotillomania	Incrementing inositol from 6 to 12 to 18 g, QD, every 2 weeks for a total duration of 10 weeks		Oral powder		Patients were “much or very much improved”	Mild GID (9) and headache (2); one hospitalization due to ectopic pregnancy	2.5
Neoplasm
Khurana et al,[@350884] 2019	Case report	A patient with stage IVB melanoma	IP6+inositol (800 mg/220 mg), 5 tablets, BID		Oral tablets		Restaging scans showed significant improvement after 6 months, complete clinical and radiological remission after 2 years	None	24

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