Treatment	Outcome Measure	N	Result
Isotretinoin	Keloid improvement	21	Out of 21 patients who were treated with isotretinoin for their acne, 8 of them had keloid lesions. 7 patients (86%) stated their lesions improved. 1 patient (13%) stated a new keloid developed during treatment.[@268377]
0.3% Adapalene	Skin appearance of atrophic scars	18	15 of the 18 subjects (83%) reported that their skin texture had improved and lesion accounts decreased for all scar types.[@268378]
A0.3/BPO2.5 (Adapalene and Benzoyl Peroxide)	Scar Count	45	21.7% decrease at week 24 and 26.9% at week 48.[@268379]
Tranilast N-(3,4-dimethoxycinnamoyl)	Global Aesthetic Improvement Scale	40	The mean GAIS scores at 5 months post-treatment were significantly lower (better outcome) for the tranilast-treated side than the placebo-treated areas in patients concomitantly treated with isotretinoin 1.36 vs 2.83, P < 0.001¹⁸
DA-5520	ECCA grading scale	36	At the final follow-up visit at 12 weeks, the percentage reduction was the highest in the test 2 group (24.36%)[@268387]
Epidermal Growth Factor	Acne lesion and scar counts	31	Scar grading scales were significantly decreased after 8 weeks from 17.03 ∓ 16.74 to 15.61∓16.74[@268388]